HIGHLY REGIO- AND syn-DIASTEREOSELECTIVE SYNTHESIS OF 4-HYDROXY-1,2-ALKADIENYLCARBAMATES FROM α-TITANATED 2-ALKYNYLCARBAMATES AND ALDEHYDES

DOI: 10.1016/S0040-4020(01)81651-3

Source and publish data:

Tetrahedron p. 2457 - 2466 (1987)

Update date:2022-08-04

Topics: Synthesis Diastereoselective Hydroxy Regioselective

Authors:

Hoppe, Dieter

Gonschorrek, Charlotte

Schmidt, Dieter

Egert, Ernst

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Article abstract of DOI:10.1016/S0040-4020(01)81651-3

N,N-Diisopropyl 2-alkynyl carbamates 9 are deprotonated by n-butyllithium to form lithium compounds 10.After exchange of the cation, titanium reagents 13 add highly diastereoselective to aldehydes with formation of the title compounds 14.In contrast to me

Full text of DOI:10.1016/S0040-4020(01)81651-3

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Product name:N,N-diisopropyl 1-(1-hydroxybenzyl)-2-butynyl carbamate

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