Phosphorus, Sulfur and Silicon and the Related Elements p. 1911 - 1922 (2008)
Update date:2022-08-02
Topics:
Akbari
Kachhadia
Tala
Bapodra
Dhaduk
Joshi
Mehta
Pathak
Some new N-(4-chlorophenyl)-6-methyl-4-aryl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5-carboxamide 4(a-h) were synthesized by the reaction of N-(4-chlorophenyl)-3-oxobutanamide, thiourea and different aromatic aldehydes. The synthesis of N-(4-chlorophenyl)-7-methyl-5-aryl-2,3-dihydro-5H-thiazolol[3, 2-a]pyrimidine-6-carboxamide 5(a-h) was accomplished by cyclocondensation of 1,2,3,4-tetrahydropyrimidine-2-thiones 4(a-h) and 1,2-dibromoethane. The structures of these compounds have been proved by IR, 1H-NMR, and Mass spectral studies. Synthesized compounds 4(a-h) and 5(a-h) were evaluated for their antimicrobial activities. Some of the compounds exhibited significant inhibition on bacterial and fungal growth as compared to standard drugs. Copyright Taylor & Francis Group, LLC.
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