One-pot synthesis of 1-arylindole-3-carboxylates from 2-(2-isocyanophenyl)acetates

Article abstract of DOI:10.3987/COM-08-11509

An efficient method for the preparation of 1-arylindole-3-carboxylates under mild conditions has been developed. Thus, cyclization of ethyl 2-(2-isocyanophenyl)acetates using sodium hydride at room temperature was followed by 1-arylation of the resulting

Full text of DOI:10.3987/COM-08-11509

HETEROCYCLES, Vol. 78, No. 1, 2009
161
HETEROCYCLES, Vol. 78, No. 1, 2009, pp. 161 – 168. © The Japan Institute of Heterocyclic Chemistry
Received, 31st July, 2008, Accepted, 12th September, 2008, Published online, 18th September, 2008.
DOI: 10.3987/COM-08-11509
ONE-POT SYNTHESIS OF 1-ARYLINDOLE-3-CARBOXYLATES
FROM 2-(2-ISOCYANOPHENYL)ACETATES
Shuhei Fukamachi, Hisatoshi Konishi, and Kazuhiro Kobayashi*
Division of Applied Chemistry, Department of Chemistry and Biotechnology,
Graduate School of Engineering, Tottori University, 4-101 Koyama-minami,
Tottori 680-8552, Japan
Abstract
-
An
efficient
method
for
the
preparation
of
1-arylindole-3-carboxylates under mild conditions has been developed. Thus,
cyclization of ethyl 2-(2-isocyanophenyl)acetates using sodium hydride at room
temperature was followed by 1-arylation of the resulting ethyl
1-sodioindole-3-carboxylates with fluoro(di)nitrobenzenes to give ethyl
1-(di)nitrophenylindole-3-carboxylates in generally good yields. This method
also allows preparation of 1,1’-(4,6-dinitro-1,3-phenylene)diindole derivatives
by using 1,3-difluoro-4,6-dinitrobenzene.
INTRODUCTION
2-(Lithiomethyl)phenyl isocyanides have been used as intermediates in syntheses of a number of indole
derivatives and related heterocycles by reactions with various electrophiles followed by cyclization.1
Methyl 2-(2-isocyanophenyl)acetate, which could be prepared by reacting 2-(lithiomethyl)phenyl
isocyanide with methyl chloroformate,2 was elaborated to the preparation of methyl indole-3-carboxylate
and methyl 3-alkyl-3H-indole-3-carboxylates by copper(I) oxide-catalyzed cyclization.3 However, any
other elaborations of 2-(2-isocyanophenyl)acetates have not been reported so far. In this report, we
describe a facile one-pot procedure for the synthesis of ethyl 1-arylindole-3-carboxylates by cyclization
of ethyl 2-(2-isocyanophenyl)acetates followed by 1-arylation with fluoro(di)nitrobenzenes under mild
conditions. Indole-3-carboxylates are synthetically as well as medicinally important heterocyclic
compounds,4 and so, several methods for their preparation have been recently reported.5 However, only
a few methods have been reported for the synthesis of 1-aryl derivatives involving construction of the
pyrrole moiety.6 Most of syntheses of 1-arylindole-3-carboxylates have been based on the
copper-catalyzed coupling reactions between indole-3-carboxylates and halobenzenes at higher
temperature.7
RESULTS AND DISCUSSION
The one-pot conversion of ethyl 2-(2-isocyanophenyl)acetates (2), which were easily prepared from

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HETEROCYCLES, Vol. 78, No. 1, 2009
2-methylphenyl isocyanides (1) on a successive treatment with lithium diisopropylamide (LDA) and
ethyl chloroformate according to the procedure reported by Ito et al,1,2 into ethyl 1-(2-[or 4-]nitro- or
2,4-dinitrophenyl)indole-3-carboxylates (5) was conducted as illustrated in Scheme 1. Thus, compounds
(2) were treated with sodium hydride in dimethyl sulfoxide (DMSO)–THF at room temperature. The
cyclization proceeded slowly (for about 3 h) to generate the corresponding ethyl 1-sodioindole-3-
carboxylates (3). Subsequent 2-(or 4-)nitro- or 2,4-dinitro-phenylation was achieved by adding
1-fluoro-2-(or 4-)nitro- or 1-fluoro-2,4-dinitro-benzenes (4) to give, after usual workup followed by
purification by preparative TLC on silica gel, the desired 1-arylindole-3-carboxylates (5). The results are
summarized in Table 1. From these results it can be seen that the 1-arylation reactions generally
proceeded very smoothly (within 30 min) and cleanly to give the desired products (5) in fair to good
yields.8 When the sequence was carried out using 1-fluoro-2,4-dinitrobenzene, the dinitroarylation
completed immediately (within 5 min) to give the corresponding ethyl 1-(2,4-dinitrophenyl)indole-3-
carboxylates (5d, g, i, and j) in good yields (Entries 4, 7, 9, and 10).9
CO2Et
R1
R1
Me
NC
R1
1. 2LDA, diglyme, –78 ˚C
2. ClCO2Et, –78 ˚C
NaH
CO2Et
DMSO-THF, rt
N
NC
2a 65%
Na
1a R1 = H
3
1b R1 = Me
1c R1 = Cl
2b 52%
2c 65%
2d 60%
CO2Et
R2
1d R1 = OMe
R1
R3
4
F
N
R2
rt
R3
5
Scheme 1
Table 1. Preparation of 1-Arylindole-3-carboxylates (5)
Entry
2
4
Time/min
5 (Yield/%)a
5a (84)
5b (82)
5c (80)
5d (91)
5e (76)
5f (76)
1
2
3
4
5
6
7
8
9
10
2a
2a
2a
2a
2b
2b
2b
2c
2c
2d
4a (R2 = NO2, R3 = H)
10
10
30
<5
10
30
<5
10
<5
<5
4b (R2 = NO2, R3 = Me)
4c (R2 = H, R3 = NO2)
4d (R2 = R3 = NO2)
4a
4c
4d
4a
4d
4d
5g (84)
5h (86)
5i (90)
5j (91)
aYields are of purified products.

HETEROCYCLES, Vol. 78, No. 1, 2009
163
We next examined the possibility of the synthesis of 1,1’-(4,6-dinitro-1,3-phenylene)diindole derivatives
7 as an application of the present cyclization-arylation sequence. As shown in Scheme 2, when
1-sodioindole-3-carboxylates (3) were treated with 1,3-difluoro-4,6-dinitrobenzene (6) (2:1 molar ratio)
under the same conditions as described for the preparation of 1-arylindole-3-carboxylates (5), the
arylation reaction also proceeded very smoothly to lead to the formation of the corresponding desired
products (7) in good-to-excellent yields. To the best of our knowledge, this type of (phenylene)diindoles
are unknown in the literature.
EtO2C
CO2Et
F
F
rt
3a, d
+
N
N
<5 min
R1
R1
O2N
NO2
O2N
NO2
6
7a R1 = H 92%
7b R1 = OMe 86%
Scheme 2
Unfortunately, however, it should be noted that the use of 2-fluorobenzonitrile instead of
fluoro(di)nitrobenzenes in the 1-arylation step using 2a resulted in the formation of an intractable
mixture of products, from which no more than a trace amount of the desired ethyl
1-(2-cyanophenyl)indole-3-carboxylates was obtained. This may be due to lability of the cyano function
under the reaction conditions.
In conclusion, 2-(2-isocyanophenyl)acetates have been utilized for the one-pot synthesis of
1-[(di)nitrophenyl]indole-3-carboxylates. Notable advantages of the present synthesis include: i)
simplicity of the procedure, ii) milder reaction conditions, iii) readily availability of the starting
materials, and iv) good yields of products. This procedure has been applied to the synthesis of
1,1’-(1,3-phenylene)diindole derivatives. Further elaboration of 2-(2-isocyanophenyl)acetates to the
preparation of other types of heterocycles is currently being pursued in our laboratory.
EXPERIMENTAL
The melting points were determined on a Laboratory Devices MEL-TEMP II melting-point apparatus
1
and are uncorrected. The IR spectra were recorded on a Shimadzu FTIR-8300 spectrometer. H NMR
spectra were determined using SiMe4 as an internal reference in CDCl3 with a JEOL ECP500 FT NMR
spectrometer operating at 500 MHz. 13C NMR spectra were determined using SiMe4 as an internal
reference with a JEOL ECP500 FT NMR spectrometer operating at 125 MHz in CDCl3. Low- and high-
resolution mass spectra (EI, 70 eV) were recorded on a JEOL JMS-AX505 HA spectrometer. Thin-layer

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chromatography (TLC) was carried out using Merck Kieselgel 60 PF254. Column chromatography was
performed using Merck Kieselgel 60 (0.063–0.200 mm). All of the solvents used were dried over the
appropriate drying agents and distilled under argon prior to use.
Starting Materials. 2-Methylphenyl isocyanides (1) were prepared by a modification1 of Ugi’s
Method.10 All other chemicals used in this study were commercially available.
Typical Procedure for the Preparation of 2-(2-Isocyanophenyl)acetates (2). Ethyl 2-(2-
Isocyanophenyl)acetate (2a). To a stirred deep-red solution of 2-lithiomethylphenyl isocyanide, which
was generated in situ by treating 1a (1.2 g, 10 mmol) with 2 molar amount of LDA in diglyme (25 mL)
at –78 ˚C, was added ethyl chloroformate (1.1 g, 10 mmol) dropwise. The color of the solution
immediately turned into light red. Saturated aqueous NH4Cl (30 mL) was added, and organic materials
were extracted with Et2O three times (30 mL each). The combined extracted was washed with water five
times and then brine once, and dried over anhydrous Na2SO4. After evaporation of the solvent, the
residue was purified by column chromatography on silica gel (1:5 THF–hexane) to give 2 (1.2 g, 65%);
1
pale-yellow needles; mp 45–46 ˚C (hexane); IR (KBr) 2122, 1732 cm–1; H NMR δ 1.28 (t, J = 7.3 Hz,
3H), 3.80 (s, 2H), 4.20 (q, J = 7.3 Hz, 2H), 7.32 (dd, J = 7.3, 1.8 Hz, 1H), 7.34–7.42 (m, 3H). Anal.
Calcd for C11H11NO2: C, 69.83; H, 5.86; N, 7.40. Found: C, 69.68; H, 6.00; N, 7.25.
Ethyl 2-(2-Isocyano-5-methylphenyl)acetate (2b): a yellow oil; Rf 0.40 (1:7 THF–hexane); IR (neat)
2120, 1737 cm–1; 1H NMR δ 1.29 (t, J = 7.3 Hz, 3H), 2.36 (s, 3H), 3.75 (s, 2H), 4.20 (q, J = 7.3 Hz, 2H),
7.11 (d, J = 7.8 Hz, 1H), 7.14 (s, 1H), 7.28 (d, J = 7.8 Hz, 1H); MS m/z 203 (M+, 100). HR-MS. Calcd
for C12H13NO2: M, 203.0946. Found: m/z 203.0958.
Ethyl 2-(5-Chloro-2-isocyanophenyl)acetate (2c): a yellow oil; Rf 0.29 (1:7 THF–hexane); IR (neat)
2122, 1738 cm–1; 1H NMR δ 1.29 (t, J = 7.3 Hz, 3H), 3.76 (s, 2H), 4.21 (q, J = 7.3 Hz, 2H), 7.30 (dd, J =
8.2, 1.8 Hz, 1H), 7.35 (d, J = 8.2 Hz, 1H), 7.36 (d, J = 1.8 Hz, 1H); MS m/z 223 (M+, 100). HR-MS.
Calcd for C11H10ClNO2: M, 223.0400. Found: m/z 223.0391.
Ethyl 2-(2-Isocyano-5-methoxylphenyl)acetate (2d): a yellow oil; Rf 0.20 (1:7 Et2O–hexane); IR
1
(neat) 2118, 1738 cm–1; H NMR δ 1.28 (t, J = 7.3 Hz, 3H), 3.75 (s, 2H), 3.82 (s, 3H), 4.20 (q, J = 7.3
Hz, 2H), 6.80 (dd, J = 8.7, 2.7 Hz, 1H), 6.85 (d, J = 2.7 Hz, 1H), 7.33 (d, J = 8.7 Hz, 1H); MS m/z 219
(M+, 100). HR-MS. Calcd for C12H13NO3: M, 219.0895. Found: m/z 219.0912.
Typical Procedure for the Preparation 1-Arylindole-3-carboxylates (5) and (7). Ethyl
1-(2-Nitrophenyl)indole-3-carboxylate (5a). To a stirred suspension of NaH (60% in oil; 21 mg, 0.53
mmol) in DMSO–THF (1:1 v/v, 2 mL) at rt was added a solution of 2 (0.10 g, 0.53 mmol) in THF (1
mL) dropwise; the mixture was stirred at the same temperature for 3 h. 1-Fluoro-2-nitrobenzene (4a) (75
mg, 0.53 mmol) was added, and stirring was continued for an additional 10 min. Saturated aqueous
NH4Cl (10 mL) was added, and organic materials were extracted with AcOEt three times (10 mL each).
The combined extracted was washed with water three times and then brine once, and dried over

HETEROCYCLES, Vol. 78, No. 1, 2009
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anhydrous Na2SO4. After evaporation of the solvent, the residue was purified by preparative TLC on
silica gel (1:3 THF–hexane) to give 5a (0.14 g, 84%); a yellow solid; mp 110–111 ˚C (hexane–CH2Cl2);
IR (KBr) 1692, 1528, 1346 cm–1; 1H NMR δ 1.44 (t, J = 7.3 Hz, 3H), 4.42 (q, J = 7.3 Hz, 2H), 7.06 (d, J
= 7.8 Hz, 1H), 7.25 (td, J = 7.3, 1.4 Hz, 1H), 7.33 (ddd, J = 7.8, 7.3, 0.9 Hz, 1H), 7.59 (dd, J = 7.8, 1.4
Hz, 1H), 7.69 (ddd, J = 7.8, 7.3, 1.4 Hz, 1H), 7.81 (ddd, J = 7.8, 7.3, 1.4 Hz, 1H), 7.90 (s, 1H), 8.13 (dd,
J = 7.8, 1.4 Hz, 1H), 8.25 (d, J = 7.3 Hz, 1H); 13C NMR δ 14.50, 60.05, 109.79, 110.80, 122.11, 122.80,
123.95, 125.79, 126.44, 129.69, 130.12, 131.64, 134.10 (two overlapped C’s), 137.42, 146.19, 164.69;
MS m/z 310 (M+, 100). Anal. Calcd for C17H14N2O4: C, 65.80; H, 4.55; N, 9.03. Found: C, 65.74; H,
4.35; N, 8.87.
Ethyl 1-(4-Methyl-2-nitrophenyl)indole-3-carboxylate (5b): a yellow solid; mp 144–145 ˚C
1
(hexane–CH2Cl2); IR (KBr) 1699, 1539, 1348 cm–1; H NMR δ 1.43 (t, J = 7.3 Hz, 3H), 2.57 (s, 3H),
4.41 (q, J = 7.3 Hz, 2H), 7.03 (d, J = 8.2 Hz, 1H), 7.24 (ddd, J = 8.2, 7.3, 1.4 Hz, 1H), 7.31 (ddd, J = 7.8,
7.3, 0.9 Hz, 1H), 7.44 (d, J = 7.8 Hz, 1H), 7.59 (ddd, J = 7.8, 1.4 Hz, 1H), 7.88 (s, 1H), 7.93 (s, 1H),
8.24 (d, J = 7.8 Hz, 1H); MS m/z 324 (M+, 100). Anal. Calcd for C18H16N2O4: C, 66.66; H, 4.97; N, 8.64.
Found: C, 66.68; H, 5.08; N, 8.39.
Ethyl 1-(4-Nitrophenyl)indole-3-carboxylate (5c): pale-yellow needles; mp 150–152 ˚C
(hexane–CH2Cl2); IR (KBr) 1686, 1545, 1346 cm–1; 1H NMR δ 1.45 (t, J = 7.3 Hz, 3H), 4.44 (q, J = 7.3
Hz, 2H), 7.35–7.40 (m, 2H), 7.58 (d, J = 7.3 Hz, 1H), 7.74 (d, J = 9.2 Hz, 2H), 8.07 (s, 1H), 8.29 (dd, J
= 7.3, 1.4 Hz, 1H), 8.45 (d, J = 9.2 Hz, 2H); MS m/z 310 (M+, 100). Anal. Calcd for C17H14N2O4: C,
65.80; H, 4.55; N, 9.03. Found: C, 65.74; H, 4.72; N, 9.24.
Ethyl 1-(2,4-Dinitrophenyl)indole-3-carboxylate (5d):
a
yellow solid; mp 165–167 ˚C
(hexane–CH2Cl2); IR (KBr) 1697, 1543, 1344 cm–1; 1H NMR δ 1.44 (t, J = 7.3 Hz, 3H), 4.43 (q, J = 7.3
Hz, 2H), 7.10 (d, J = 8.2 Hz, 1H), 7.32 (ddd, J = 8.2, 7.3, 1.4 Hz, 1H), 7.38 (ddd, J = 8.2, 7.3, 0.9 Hz,
1H), 7.86 (d, J = 8.7 Hz, 1H), 7.88 (s, 1H), 8.28 (d, J = 8.2 Hz, 1H), 8.65 (dd, J = 8.7, 2.3 Hz, 1H), 8.98
(d, J = 2.3 Hz, 1H); MS m/z 355 (M+, 100). Anal. Calcd for C17H13N3O6: C, 57.47; H, 3.69; N, 11.83.
Found: C, 56.43; H, 3.56; N, 11.44
Ethyl 5-Methyl-1-(2-nitrophenyl)indole-3-carboxylate (5e): a yellow oil; Rf 0.39 (1:4 THF–hexane);
1
IR (neat) 1699, 1533, 1350 cm–1; H NMR δ 1.43 (t, J = 7.3 Hz, 3H), 2.49 (s, 3H), 4.41 (q, J = 7.3 Hz,
2H), 6.94 (d, J = 8.2 Hz, 1H), 7.07 (dd, J = 8.2, 1.4 Hz, 1H), 7.58 (dd, J = 8.2, 1.4 Hz, 1H), 7.67 (ddd, J
= 8.2, 7.3, 1.4 Hz, 1H), 7.80 (ddd, J = 8.2, 7.3, 1.4 Hz, 1H), 7.85 (s, 1H), 8.05 (s, 1H), 8.11 (dd, J = 8.2,
1.4 Hz, 1H); MS m/z 324 (M+, 100). Anal. Calcd for C18H16N2O4: C, 66.66; H, 4.97; N, 8.64. Found: C,
66.64; H, 4.94; N, 8.64.
Ethyl 5-Methyl-1-(4-nitrophenyl)indole-3-carboxylate (5f): a yellow solid; mp 165–167 ˚C
1
(hexane–CH2Cl2); IR (KBr) 1684, 1549, 1342 cm–1; H NMR δ 1.45 (t, J = 7.3 Hz, 3H), 2.52 (s, 3H),
4.43 (q, J = 7.3 Hz, 2H), 7.18 (d, J = 8.2 Hz, 1H), 7.47 (d, J = 8.2 Hz, 1H), 7.72 (d, J = 8.7 Hz, 2H), 8.02

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(s, 1H), 8.08 (s, 1H), 8.44 (d, J = 8.7 Hz, 2H); MS m/z 324 (M+, 100). Anal. Calcd for C18H16 N2O4: C,
66.66; H, 4.97; N, 8.64. Found: C, 66.39; H, 4.90; N, 8.41.
Ethyl 1-(2,4-Dinitrophenyl)-5-methylindole-3-carboxylate (5g): a yellow solid; mp 132–134 ˚C
1
(hexane–CH2Cl2); IR (KBr) 1678, 1541, 1346 cm–1; H NMR δ 1.44 (t, J = 7.3 Hz, 3H), 2.50 (s, 3H),
4.43 (q, J = 7.3 Hz, 2H), 6.99 (d, J = 8.2 Hz, 1H), 7.12 (d, J = 8.2 Hz, 1H), 7.83 (s, 1H), 7.84 (d, J = 8.7
Hz, 1H), 8.07 (s, 1H), 8.63 (dd, J = 8.7, 2.7 Hz, 1H), 8.97 (d, J = 2.7 Hz, 1H); 13C NMR δ 14.51, 21.52,
60.34, 109.07, 112.44, 121.84, 122.33, 126.24, 127.12, 128.39, 130.52, 132.94, 133.49, 134.97, 137.02,
145.21, 146.54, 164.25; MS m/z 369 (M+, 100). Anal. Calcd for C18H15N3O6: C, 58.54; H, 4.09; N, 11.38.
Found: C, 58.66; H, 4.17; N, 11.07.
Ethyl 5-Chloro-1-(2-nitrophenyl)indole-3-carboxylate (5h): a yellow solid; mp 128–130 ˚C
(hexane–CH2Cl2); IR (KBr) 1690, 1535, 1364 cm–1; 1H NMR δ 1.44 (t, J = 7.3 Hz, 3H), 4.42 (q, J = 7.3
Hz, 2H), 6.96 (d, J = 8.7 Hz, 1H), 7.21 (dd, J = 8.7, 2.3 Hz, 1H), 7.57 (d, J = 7.8 Hz, 1H), 7.71 (ddd, J =
7.8, 7.3, 1.4 Hz, 1H), 7.82 (ddd, J = 7.8, 7.3, 1.4 Hz, 1H), 7.90 (s, 1H), 8.14 (d, J = 7.8 Hz, 1H), 8.23 (d,
J = 2.3 Hz, 1H); MS m/z 344 (M+, 100). Anal. Calcd for C17H13ClN2O4: C, 59.23; H, 3.80; N, 8.13.
Found: C, 59.22; H, 3.83; N, 7.84.
Ethyl 5-Chloro-1-(2,4-dinitrophenyl)indole-3-carboxylate (5i): an orange solid; mp 182–183 ˚C
(hexane–CH2Cl2); IR (KBr) 1607, 1535, 1366 cm–1; 1H NMR δ 1.46 (t, J = 7.3 Hz, 3H), 4.44 (q, J = 7.3
Hz, 2H), 7.00 (d, J = 9.2 Hz, 1H), 7.27 (dd, J = 9.2, 1.8 Hz, 1H), 7.85 (d, J = 8.7 Hz, 1H), 7.88 (s, 1H),
8.26 (d, J = 1.8 Hz, 1H), 8.67 (dd, J = 8.7, 2.7 Hz, 1H), 8.99 (d, J = 2.7 Hz, 1H); MS m/z 389 (M+, 100).
Anal. Calcd for C17H12ClN3O6: C, 52.39; H, 3.10; N, 10.78. Found: C, 52.34; H, 3.20; N, 10.68.
Ethyl 1-(2,4-Dinitrophenyl)-5-methoxylindole-3-carboxylate (5j): an orange solid; mp 190–191 ˚C
(hexane–THF); IR (KBr) 1682, 1607, 1541, 1346 cm–1; 1H NMR δ 1.43 (t, J = 7.3 Hz, 3H), 3.91 (s, 3H),
4.42 (q, J = 7.3 Hz, 2H), 6.93 (dd, J = 8.7, 2.3 Hz, 1H), 7.00 (d, J = 8.7 Hz, 1H), 7.75 (d, J = 2.3 Hz, 1H),
7.81 (s, 1H), 7.85 (d, J = 8.7 Hz, 1H), 8.63 (dd, J = 8.7, 2.3 Hz, 1H), 8.96 (d, J = 2.3 Hz, 1H); MS m/z
385 (M+, 100). Anal. Calcd for C18H15N2O7: C, 56.11; H, 3.92; N, 10.91. Found: C, 56.07; H, 4.02; N,
10.85.
Ethyl 1-[2,4-Dinitrophenyl-5-(3-ethoxycarbonylindol-1-yl)]indole-3-carboxylate (7a): an orange-
yellow solid; mp 103–105 ˚C (hexane–CH2Cl2); IR (KBr) 1699, 1539, 1339 cm–1; 1H NMR δ 1.44 (t, J =
7.3 Hz, 6H), 4.43 (q, J = 7.3 Hz, 4H), 7.18 (d, J = 8.2 Hz, 2H), 7.36 (ddd, J = 8.2, 7.3, 1.4 Hz, 2H), 7.40
(ddd, J = 7.8, 7.3, 1.4 Hz, 2H), 7.90 (s, 2H), 7.91 (s, 1H), 8.28 (d, J = 7.8 Hz, 2H), 8.95 (s, 1H);13C
NMR δ 14.45, 60.49, 109.24, 113.40, 122.84, 123.92, 124.85, 125.05, 126.86, 130.15, 132.73, 136.45,
136.59, 143.15, 163.93; MS m/z 542 (M+, 100). Anal. Calcd for C28H22N4O8: C, 61.99; H, 4.09; N, 10.33.
Found: C, 61.66; H, 4.36; N, 10.06.
Ethyl
1-[2,4-Dinitrophenyl-5-(3-ethoxycarbonyl-5-methoxyindol-1-yl)]-5-methoxyindole-3-
carboxylate (7b): a yellow solid; mp 212–214 ˚C (hexane–CH2Cl2); IR (KBr) 1695, 1616, 1541, 1346

HETEROCYCLES, Vol. 78, No. 1, 2009
167
cm–1; 1H NMR δ 1.43 (t, J = 7.3 Hz, 6H), 3.91 (s, 6H), 4.42 (q, J = 7.3 Hz, 4H), 6.97 (dd, J = 8.7, 2.7 Hz,
2H), 7.06 (d, J = 8.7 Hz, 2H), 7.74 (d, J = 2.7 Hz, 2H), 7.84 (s, 2H), 7.88 (s, 1H), 8.90 (s, 1H); MS m/z
602 (M+, 100). Anal. Calcd for C30H26N4O10: C, 59.80; H, 4.35; N, 9.30. Found: C, 59.68; H, 4.40; N,
9.13.
ACKNOWLEDGEMENTS
We are grateful to Mrs. Miyuki Tanmatsu of this University for her support in determining mass spectra
and performing combustion analyses.
REFERENCES AND NOTES
1. Y. Ito, K. Kobayashi, N. Seko, and T. Saegusa, Bull. Chem. Soc. Jpn., 1984, 57, 73 and pertinent
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2. Y. Ito, K. Kobayashi, and T. Saegusa, J. Am. Chem. Soc., 1977, 99, 3532.
3. Y. Ito, Y. Inubushi, T. Sugaya, K. Kobayashi, and T. Saegusa, Bull. Chem. Soc. Jpn., 1978, 51,
1186.
4. For recent reports on the biological activity of indole-3-carboxylates: (a) Anti-hepatitis B virus
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