14β-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity

DOI: 10.1021/jm8012272

Source and publish data:

Journal of Medicinal Chemistry p. 1553 - 1557 (2009)

Update date:2022-09-26

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Authors:

Moynihan

Jales Jales

Greedy Greedy

Rennison

Broadbear

Purington

Traynor Traynor

Woods Woods

Lewis Lewis

Husbands

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Article abstract of DOI:10.1021/jm8012272

14-O-Cinnamoyl esters of naltrexone (6) were synthesized and evaluated in isolated tissue assays in vitro and in vivo in mouse antinociceptive assays. Their predominant opioid receptor activity was mu receptor (MOR) antagonism, but the unsubstituted cinna

Full text of DOI:10.1021/jm8012272

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