Bioorganic and Medicinal Chemistry Letters p. 6651 - 6655 (2007)
Update date:2022-08-04
Topics:
Mukherjee, Shubhasish
Robinson, Carolyn A.
Howe, Andrew G.
Mazor, Tali
Wood, Peter A.
Urgaonkar, Sameer
Hebert, Alan M.
RayChaudhuri, Debabrata
Shaw, Jared T.
A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli. Although the lead screening hit (534F6) exhibited modest inhibition of the GTPase activity of FtsZ (20 ± 5% at 100 μM of compound), a primary target for bacterial cell division inhibitors, several analogs caused potent bacterial growth inhibition with negligible antagonism of FtsZ GTPase activity. A library of analogs has been prepared and several alkyne-tagged photoaffinity probes have been synthesized for use in experiments to elucidate the primary target of this compound.
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