Journal of Organic Chemistry p. 2323 - 2327 (1988)
Update date:2022-07-31
Topics:
Lalonde, James J.
Bergbreiter, David E.
Wong, C.-H.
Synthetic routes to various quaternary α-nitro α-methyl carboxylic acid esters from simpler nitroalkanes and nitroalkane derivatives are described.These quaternary α-amino acid precursors can be kinetically resolved by using α-chymotrypsin.It was found that partial hydrolysis of these α-nitro α-methyl esters and recovery of the unhydrolyzed ester proceeds preferentially by hydrolysis of the D enantiomer.Reduction of the α-nitro group thus then affords highly enantiomerically enriched L-α-methyl α-amino acids.
View MoreShandong Zhongcheng Barium Salt Co., Ltd
Contact:+86-15725732638
Address:No.29 baoxi road, hi-tech zone, zibo, shandong
Contact:18669908765
Address:Zibo City, Shandong Province, P.R.China
Contact:0086-357-6662688
Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
Sichuan Sangao Biochemical Co., Ltd
Contact:+86-28-84874233
Address:19F, Bldg.2, Shudu Center, Tianfu 2nd St., Hi-tech zone, Chengdu 610041, Sichuan Province, China.
Contact:+86-27-67841589
Address:Add: 999 Gaoxin Road, Donghu New Technology Development Zone, Wuhan City, Hubei, China
Doi:10.1016/j.cclet.2015.10.029
(2016)Doi:10.1002/chem.200802144
(2009)Doi:10.1055/s-0028-108766
(2009)Doi:10.1021/jm00401a002
(1988)Doi:10.1002/chem.200801911
(2009)Doi:10.1016/j.tetlet.2009.01.130
(2009)
