
Bioorganic and Medicinal Chemistry Letters p. 1089 - 1092 (1996)
Update date:2022-07-29
Topics:
Boger
Zhou
Borzilleri
Nukui
A synthesis of the (9S,12S)-cycloisodityrosine derivatives and their unnatural (9R,12S)-diastereomers are disclosed. The approach is based on an intramolecular aromatic nucleophilic substitution reaction for formation of the macrocyclic biaryl ether and includes the documentation of a remarkably facile base-catalyzed epimerization.
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