Synthesis and optical resolution of dl-cis-2-fluorocyclopropylamine, the key component of the new generation of quinolonecarboxylic acid, DU-6859

DOI: 10.1016/S0040-4039(00)92669-8

Source and publish data:

Tetrahedron Letters p. 3483 - 3486 (1992)

Update date:2022-08-02

Topics:

Authors:

Tamura Tamura

Hashimoto

Kobayashi

Katoh Katoh

Nakatani

Kamada Kamada

Hayakawa

Akiba Akiba

Terashima

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Article abstract of DOI:10.1016/S0040-4039(00)92669-8

The title synthesis was accomplished by featuring highly cis-selective cyclopropanation of an N-vinylcarbamate with zinc-monofluorocarbenoid followed by deprotection of the formed N-(cis-2-fluorocyclopropyl)carbamate. Optical resolution of dl-cis-2-fluoro

Full text of DOI:10.1016/S0040-4039(00)92669-8

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