Tetrahedron p. 4803 - 4816 (1987)
Update date:2022-08-04
Topics: Total synthesis Alkaloid Starting Materials Reaction Steps Aaptamine
Andrew, Robert G.
Raphael, Ralph A.
A new synthesis of the α-adrenoceptor blocker aaptamine (1) from the readily available 5-nitrovanillin is reported.An unusual intramolecular nucleophilic displacement of a nitro-group is described.
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