Tetrahedron p. 4803 - 4816 (1987)
Update date:2022-08-04
Topics: Total synthesis Alkaloid Starting Materials Reaction Steps Aaptamine
Andrew, Robert G.
Raphael, Ralph A.
A new synthesis of the α-adrenoceptor blocker aaptamine (1) from the readily available 5-nitrovanillin is reported.An unusual intramolecular nucleophilic displacement of a nitro-group is described.
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Doi:10.1002/hlca.19890720107
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(2012)Doi:10.1021/ol9004432
(2009)Doi:10.1002/chem.201804786
(2018)Doi:10.1016/S0040-4039(00)96350-0
(1987)Doi:10.1002/mrc.2638
(2010)
