The reaction usually begins with the formation of an enolate of the acylphosphonate. This enolate is generated by deprotonation of the acylphosphonate using a base. The chiral catalyst plays a crucial role in controlling the stereochemistry. It might coordinate with the enolate to help direct the reaction. The nucleophilic enolate then attacks the electrophilic center on the 3-alkylidene oxindole. This forms a carbon-carbon bond and generates the vinylogous aldol product. The stereochemistry of the product is controlled by the chiral catalyst, leading to high enantioselectivity.
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C27H50OP(1+)*NO3(1-)
C36H25N2O2P
2-Bromo-6-Isopropylpyridine
N-Phenyl-N-<3-(4-chlorphenyl)-4-phenylisoxazol-5-yl>-aminoessigsaeure
2-(2,4,6-trimethylphenyl)-2H-indazole
(E)-1-(3,4-dimethoxy-5-nitrophenyl)-2-nitroethene
Benzenecarboximidamide, N-(3,4-dimethylphenyl)-
