Chemical and Pharmaceutical Bulletin p. 678 - 684 (1997)
Update date:2022-08-04
Topics:
Kuroda, Tooru
Kondo, Kazuhiko
Iwasaki, Tameo
Ohtani, Akio
Takashima, Kohki
A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. The diesters with modifications at C-3 showed excellent hypocholesterolemic and high-density lipoprotein (HDL) cholesterol-elevating activities. Structure- activity analysis indicated that the 2-pyridylmethyl ester 51 has the optimum activity.
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