Synthesis and hypolipidemic activity of diesters of arylnaphthalene lignan and their heteroaromatic analogs

DOI: 10.1248/cpb.45.678

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 678 - 684 (1997)

Update date:2022-08-04

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Authors:

Kuroda, Tooru

Kondo, Kazuhiko

Iwasaki, Tameo

Ohtani, Akio

Takashima, Kohki

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Article abstract of DOI:10.1248/cpb.45.678

A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. The diesters with modifications at C-3 showed excellent hypocholesterolemic and high-density lipoprotein (HDL) cholesterol-elevating activities. Structure- activity analysis indicated that the 2-pyridylmethyl ester 51 has the optimum activity.

Full text of DOI:10.1248/cpb.45.678

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Product name:2,3-Naphthalenedicarboxylic acid, 4-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-1-(methoxymethoxy)-, 3-methyl ester

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