Synthesis, pharmacological action, and receptor binding affinity of the enantiomeric 1-(1-phenyl-3-methylcyclohexyl)piperidines

DOI: 10.1021/jm00403a023

Source and publish data:

Journal of Medicinal Chemistry p. 1625 - 1628 (1988)

Update date:2022-07-30

Topics:

Authors:

Thurkauf

Hillery Hillery

Mattson Mattson

Jacobsen

Rice Rice

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Article abstract of DOI:10.1021/jm00403a023

The cis and trans enantiomers of the 1-(1-phenyl-3-methylcyclohexyl)piperidines were prepared from either 3(R)- or 3(S)-methylcyclohexanone through the Bruylents reaction or a modified azide route, respectively. Separation of the intermediate amines (5 an

Full text of DOI:10.1021/jm00403a023

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