Synthesis, pharmacological action, and receptor binding affinity of the enantiomeric 1-(1-phenyl-3-methylcyclohexyl)piperidines

DOI: 10.1021/jm00403a023

Source and publish data:

Journal of Medicinal Chemistry p. 1625 - 1628 (1988)

Update date:2022-07-30

Topics:

Authors:

Thurkauf

Hillery Hillery

Mattson Mattson

Jacobsen

Rice Rice

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00403a023

The cis and trans enantiomers of the 1-(1-phenyl-3-methylcyclohexyl)piperidines were prepared from either 3(R)- or 3(S)-methylcyclohexanone through the Bruylents reaction or a modified azide route, respectively. Separation of the intermediate amines (5 an

Full text of DOI:10.1021/jm00403a023

Products guided by the article

Product name:N-(1(S)-phenyl-3(R)-methylcyclohexyl)-5-chlorovaleramide

Cas No:114693-38-8

R&D Labs maybe for 114693-38-8

Shandong Topscience Biotech Co., Ltd.

Contact:0633-2619278

Address:No. 98 Lanshan West Road, Lanshan District, Rizhao, Shandong Province, P.R. of China
Nanjing Chemical Material Corp.(NCMC)

website:http://www.njchemm.com

Contact:0086-25-83172879

Address:B12 Technology and Innovation Building, Nanjing Tech University, No.5 New Model Road
QINGDAO TAOSIGN INTERNATIONAL TRADE CO.,LIMITED

Contact:+86-0532-82683616

Address:RM1402, Doublestar Seacoase 7#, No. 5 Guizhou Road, Qingdao, Shandong, China
Henan Harvest Chem Co., Ltd

Contact:+86-371-86058576

Address:NO.32, Jingsan Road, Zhengzhou, China
Jiaozuo Zhongwei Special Products Pharmaceutical Co.,Ltd.

website:http://www.zw-pvp.com

Contact:15302105619

Address:Jiaozuo,Henan,China (Mainland)

Relevant to this article

Reaction between 1,3-dicarbonyl-containing CH acids and dialkyl acetylenedicarboxylates in the presence of silica gel in solvent-free conditions: An efficient method for the synthesis of electron-poor alkenes and pyranes

Doi:10.1080/00397910802517830
(2009)
Generation of Sulfur Ylides from Sulfonium Salts and Their Reactions. Comparative Study of Electrochemical Reduction with the Base Method and Mechanism Elucidation by the MO Method

Doi:10.1246/bcsj.76.2155
(2003)
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT_1A activity, Part 1

Doi:10.1016/j.ejmech.2008.09.021
(2009)
Synthesis of a halo-methylphenylene periphery-functionalized triazine-based dendritic molecule with a 3,3′-dimethyl-biphenyl linker using tris(halo-methylphenylene)triazines as building blocks

Doi:10.1016/j.tetlet.2009.02.011
(2009)
Syntheses and Phytotoxicity of All Stereoisomers of 6-(2-Hydroxy-6-phenylhex-1-yl)-5,6-dihydro-2 H-pyran-2-one and Determination of the Effect of the α,β-Unsaturated Carbonyl Structure and Hydroxy Group Bonding to Chiral Carbon

Doi:10.1021/acs.jafc.9b05507
(2019)
Chiral Lithiated Allylic α-Sulfonyl Carbanions: Experimental and Computational Study of Their Structure, Configurational Stability, and Enantioselective Synthesis

Doi:10.1002/chem.201503123
(2015)

Article Doi