A New Stereoselective Synthesis of (20R)- and (20S)-Steroidal Side Chains

DOI: 10.1039/c39880000342

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 342 - 344 (1988)

Update date:2022-08-02

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Authors:

Ibuka, Toshiro

Taga, Tooru

Nishii, Shinji

Yamamoto, Yoshinori

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Article abstract of DOI:10.1039/c39880000342

Reaction of (E)-ethyl 3β-t-butyldimethylsiloxypregna-5,17-dien-21-oate with lithium di-isopropylamide followed by alkyl halides results in the predominant formation of (20S)-alkylation products in >88percent isolated yields; a synthetic application to both (20R)- and (20S)-steroidal side chains is also described.

Full text of DOI:10.1039/c39880000342

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