A Highly Stereoselective Synthesis of Podophyllotoxin and Analogues Based on an Intramolecular Diels-Alder Reaction

DOI: 10.1021/jo00251a003

Source and publish data:

Journal of Organic Chemistry p. 3663 - 3669 (1988)

Update date:2022-08-03

Topics:

Authors:

Macdonald, D.I.

Durst, T.

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Article abstract of DOI:10.1021/jo00251a003

A synthesis of podophyllotoxin and several analogues is described.The key step that generates all four chiral centers of podophylotoxin involves an intramolecular Diels-Alder reaction between an appropriately substituted o-quinodimethane and a pendant cro

Full text of DOI:10.1021/jo00251a003

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