Synthesis p. 978 - 981 (1987)
Update date:2022-08-04
Topics:
Fiandor, Jose
Garcia-Lopez, Maria-Teresa
Heras, Federico G. De las
Mendez-Castrillon, Paloma P.
The synthesis of six modified polyoxin derivatives containing an alkylamino group replacing the peptide bond has been accomplished, in a one pot reaction, by condensation of 2',3'-O-isopropylideneuridine-5'-aldehyde with trimethylsilyl cyanide, boron trifluoride etherate and an amino acid, in methanol.The reaction affords stereoselectively the diastereoisomer having at C-5' the same absolute configuration as the natural polyoxins.
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Doi:10.1021/jm201238p
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(1974)
