Synthesis and Antiviral Evaluation of 6'-Substituted Aristeromycins: Potential Mechanism-Based Inhibitors of S-Adenosylhomocysteine Hydrolase

DOI: 10.1021/jm00117a021

Source and publish data:

Journal of Medicinal Chemistry p. 1798 - 1804 (1988)

Update date:2022-08-05

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Authors:

Madhavan, G. V. Bindu

McGee, Danny P. C.

Rydzewski, Robert M.

Boehme, Richard

Martin, John C.

Prisbe, Ernest J.

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Article abstract of DOI:10.1021/jm00117a021

New carboxylic adenosine analogues substituted at the 6'-position with fluorine, hydroxyl, methylene, of hydroxymethyl have been synthesized as potential mechanism-based inhibitors of S-adenosylhomocysteine (AdoHcy) hydrolase.The synthetic routes began wi

Full text of DOI:10.1021/jm00117a021

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