An efficient and general method for the reformatsky-type reaction of chlorodifluoromethyl ketones with carbonyl compounds giving α,α-difluoro-β-hydroxy ketones1)

DOI: 10.1246/bcsj.63.428

Source and publish data:

Bulletin of the Chemical Society of Japan p. 428 - 437 (1990)

Update date:2022-07-29

Topics:

Authors:

Kuroboshi

Ishihara

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/bcsj.63.428

Chlorodifluoromethyl ketones CF₂ClCOR, where R is an alkyl, aryl, and l-alkynyl group, underwent the Reformatsky-type aldol reaction with a wide variety of aldehydes or ketones in the presence of acid-washed zinc dust and copper(I) chloride or

Full text of DOI:10.1246/bcsj.63.428

Products guided by the article

Product name:(E)-1-cyclohexyl-2,2-difluoro-3-hydroxy-4-hexen-1-one

Cas No:115818-48-9

R&D Labs maybe for 115818-48-9

Jiangsu Zenji Pharmaceuticals LTD

Contact:+86-025-83172562; +1-224-888-1133(USA)

Address:No.5 Xinmofan Road
Shandong Jusage Technology Co.,Ltd.

Contact:86-13406130167

Address:No.20,North Ride No.9 Road, Guangrao Economic Development Zone, Shandong Province
Nanjing Qirui Material Co., Ltd.

Contact:+86-25-52320053

Address:F4-5, #17 Building, Chuang Yi Yuan, No.6 Guanghua East Street, Nanjing, 210007 P.R.China
Jiangxi Hessence Chemicals Co., Ltd.

Contact:+86 796 3511924

Address:Chengxi Industrial Park, Jishui County, Jiangxi Province 331600 China.
SHANGHAI BIOSUNDRUG CO.,LTD.

Contact:86-21-34622192，13917187091，21-34622765

Address:No. 500 Caobao Road Shanghai P.R China

Relevant to this article

Exploration of the reaction of potassium organotrifluoroborates with porphyrins

Doi:10.1016/j.tetlet.2009.03.098
(2009)
Ruthenium-catalyzed synthesis of: N -substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

Doi:10.1039/c9cc06339k
(2019)
Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials

Doi:10.1016/j.bmcl.2009.03.026
(2009)
Synthesis of α,β-Unsaturated Amidines through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides

Doi:10.1021/acs.joc.7b01689
(2017)
Design, synthesis, and biological evaluation of new 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1,2,3-triazole derivatives

Doi:10.1007/s10593-018-2319-6
(2018)
ENZYMATIC SYNTHESIS OF ASPARTYL-CONTAINING DIPEPTIDES

Doi:10.1016/S0040-4020(01)81726-9
(1988)

Article Doi