An efficient and general method for the reformatsky-type reaction of chlorodifluoromethyl ketones with carbonyl compounds giving α,α-difluoro-β-hydroxy ketones1)

DOI: 10.1246/bcsj.63.428

Source and publish data:

Bulletin of the Chemical Society of Japan p. 428 - 437 (1990)

Update date:2022-07-29

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Authors:

Kuroboshi

Ishihara

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Article abstract of DOI:10.1246/bcsj.63.428

Chlorodifluoromethyl ketones CF₂ClCOR, where R is an alkyl, aryl, and l-alkynyl group, underwent the Reformatsky-type aldol reaction with a wide variety of aldehydes or ketones in the presence of acid-washed zinc dust and copper(I) chloride or

Full text of DOI:10.1246/bcsj.63.428

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