An efficient and general method for the reformatsky-type reaction of chlorodifluoromethyl ketones with carbonyl compounds giving α,α-difluoro-β-hydroxy ketones1)

DOI: 10.1246/bcsj.63.428

Source and publish data:

Bulletin of the Chemical Society of Japan p. 428 - 437 (1990)

Update date:2022-07-29

Topics:

Authors:

Kuroboshi

Ishihara

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/bcsj.63.428

Chlorodifluoromethyl ketones CF₂ClCOR, where R is an alkyl, aryl, and l-alkynyl group, underwent the Reformatsky-type aldol reaction with a wide variety of aldehydes or ketones in the presence of acid-washed zinc dust and copper(I) chloride or

Full text of DOI:10.1246/bcsj.63.428

Products guided by the article

Product name:(E)-1-cyclohexyl-2,2-difluoro-3-hydroxy-4-hexen-1-one

Cas No:115818-48-9

R&D Labs maybe for 115818-48-9

Shandong General Materials Co.,Ltd（Shandong Aoertong Chemical Co., Ltd）

Contact:86-531-88072280

Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
Anhui New Star Pharmaceutical Development Co., Ltd

Contact:013956922763

Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
Shanghai Bocimed Pharmaceutical Co., Ltd.

website:http://www.bocimed.com

Contact:+86-21-68861632

Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
shijiazhuang shuanglian chemical industry co.,ltd

Contact:0311-82190302

Address:Luquan Intersection , Shijiazhuang--Taiyuan Expressway，Shijiazhuang City
JADECHEM NINGBO CO.,LTD.

Contact:+86-574-89075960

Address:#100 Xiang Yun Road, New High tech area, Ningbo, China

Relevant to this article

Exploration of the reaction of potassium organotrifluoroborates with porphyrins

Doi:10.1016/j.tetlet.2009.03.098
(2009)
Ruthenium-catalyzed synthesis of: N -substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines

Doi:10.1039/c9cc06339k
(2019)
Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials

Doi:10.1016/j.bmcl.2009.03.026
(2009)
Synthesis of α,β-Unsaturated Amidines through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides

Doi:10.1021/acs.joc.7b01689
(2017)
Design, synthesis, and biological evaluation of new 1-aryl-4-(β-D-fructopyranos-3-O-yl)methyl-1H-1,2,3-triazole derivatives

Doi:10.1007/s10593-018-2319-6
(2018)
ENZYMATIC SYNTHESIS OF ASPARTYL-CONTAINING DIPEPTIDES

Doi:10.1016/S0040-4020(01)81726-9
(1988)

Article Doi