Tetrahedron p. 2185 - 2192 (1988)
Update date:2022-07-29
Topics:
Adisson, Laurence
Bolte, Jean
Demuynck, Colette
Mani, Jean-Claude
We show that the ability of thermolysin to catalyze the coupling of aspartyl residue with other aminoacids is restricted to phenylalanine.Esterification of the two carboxylic groups of N-protected aspartic acid allows chymotrypsin and papain to catalyze the desired synthesis.
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