ENZYMATIC SYNTHESIS OF ASPARTYL-CONTAINING DIPEPTIDES

DOI: 10.1016/S0040-4020(01)81726-9

Source and publish data:

Tetrahedron p. 2185 - 2192 (1988)

Update date:2022-07-29

Topics:

Authors:

Adisson, Laurence

Bolte, Jean

Demuynck, Colette

Mani, Jean-Claude

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Article abstract of DOI:10.1016/S0040-4020(01)81726-9

We show that the ability of thermolysin to catalyze the coupling of aspartyl residue with other aminoacids is restricted to phenylalanine.Esterification of the two carboxylic groups of N-protected aspartic acid allows chymotrypsin and papain to catalyze the desired synthesis.

Full text of DOI:10.1016/S0040-4020(01)81726-9

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