Helvetica Chimica Acta p. 2201 - 2214 (1987)
Update date:2022-07-30
Topics:
Oppolzer, Wolfgang
Poli, Giovanni
Kingma, Arend J.
Starkemann, Christian
Bernardinelli, Gerald
The 1,4-addition of alkylmagnesium chlorides to conjugated N-enoylsultams and subsequent 'enolate trapping' with aq.NH4Cl or MeI/hexamethylphosphoric triamide generated centers of asymmetry at C(β) and/or at C(α) with good to excellent ?-face differentation as demonstrated by the conversions 1->2, 1->4, and 8->9.This holds also for the regioselective 1,4-addition of EtMgCl to a dienosultam (15->16).Reactive conformations 1<*>, 8<*>, 13, and 14 are postulated in agreement with X-ray evidence which also served for the structure determination of the product 9j.
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Doi:10.1021/ja903351a
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(2012)Doi:10.1002/oms.1210220202
(1987)Doi:10.1021/acs.orglett.8b02240
(2018)Doi:10.1016/S0277-5387(00)81224-3
(1988)Doi:10.1002/chem.200802192
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