Journal of Organic Chemistry p. 5519 - 5527 (1988)
Update date:2022-07-31
Topics:
Evans, Jonathan C.
Klix, Russell C.
Bach, Robert D.
A series of model compounds related to the antitumor and antibiotic compound fredericamycin A has been prepared.Spiro<3-cyclopentene-1,1'-indan>-2,5-dione (2) has been prepared and established as a novel spiro dienophile in the Diels-Alder reaction with 1,3-butadiene, Danishefsky's diene, a triacetoxy-substituted o-quinodimethane, and two isobenzofuran intermediates.Thus, the cycloaddition of 3-cyano-4,5,7-trimethoxy-1(3H)-isobenzofuranone (35) and 2 afforded 4,9-dihydroxy-5,6,8-trimethoxyspiro<2H-benz
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()Doi:10.1055/s-1988-27460
(1988)