Journal of the Chemical Society. Perkin transactions I p. 725 - 732 (1988)
Update date:2022-07-30
Topics:
Yamamoto, Yohsuke
Sakaguchi, Akira
Yoshida, Hiroshi
Akiba, Kin-ya
Reactions of N-silyl- or N-acyl-pyrimidinium salts with enol trimethylsilyl ethers were carried out to afford the adducts with a 2-oxoalkyl group, that is, 2-hydroxy-4-(2-oxoalkyl)-1,2,3,4-tetrahydro-pyrimidines (9) or the 3-acyl derivatives (8), respectively.Monoacylation of compounds (9) gave monoamides (8) in high yields.Exhaustive acylation of diamines (9) with a large excess of 2,2,2-trichloroethyl chloroformate in the presence of pyridine gave bicyclic compounds, 2-oxa-8,9-diazabicyclo<3.3.1>nona-3,6-dienes (14).By addition of trifluoroacetic acid, compounds (14) were reopened to afford 3,4-dihydropyrimidinium salts (11'), which were subjected to nucleophilic attack to give 1,2,3,4-tetrahydopyrimidines (16) in high yield.
View MoreShanghai Yurui Biotechnology(Anyang) Pharmaceutical Co., Ltd
Contact:+86-0372-3662335 +86-0372-3661988
Address:hanling industrial park anyang
KA-SHING Business Trade Macau Co., Ltd.
Contact:00853-28430045
Address:23rd Floor, Block 3 La Cite, Areia Preta, Macao
Contact:86-512-69362780,69362785
Address:No.69 Weixin Road,Weiting Town,Suzhou Industrial Park
Zhengzhou Yuanli Biological Technology Co., Ltd.
Contact:+86-371-67897870/67897895
Address:No. 38, Qingyang Street, Zhengzhou, Henan, China
Shenzhen Sunrising Industry Co., ltd.
Contact:+86 755 86571158 / 86571159 / 86571160
Address:2108 ZHENYE INT. BUSINESS CENTER,NO.3101-90 QIANHAI RD, NANSHAN,SHENZHEN, CHINA
Doi:10.1016/j.tetasy.2009.03.001
(2009)Doi:10.1021/jo00258a024
(1988)Doi:10.1021/ic900198h
(2009)Doi:10.1016/j.jorganchem.2008.03.031
(2008)Doi:10.1016/j.tetlet.2009.03.069
(2009)Doi:10.1016/S0020-1693(00)87511-8
(1988)
