Journal of Organic Chemistry p. 5446 - 5453 (1988)
Update date:2022-09-26
Topics:
Tsujii, Shinji
Rinehart, Kenneth L.
Gunasekera, Sarath P.
Kashman, Yoel
Cross, Susan S.
et al.
Isolation and structure elucidation of topsentin (1) and bromotopsentin (2) are described.These novel indole alkaloids have been shown to have antitumor and antiviral activities.Their structures were determined on the basis of spectral data, and bromotopsentin was correlated structurally with topsentin by catalytic debromination.Syntheses of 1 and several analogues are also reported.
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