18. High-Yield Synthesis of 20-, 24-, and 28-Memebered Macropentolide, -hexolide, and -heptolide, Respectively, from (R)- or (S)-3-Hydroxybutanoic Acid under Yamaguchi's Macrolactonization Conditions

Article abstract of DOI:10.1002/hlca.19880710119

The macrocyclic pentolide 1, hexolide 2, and heptolide 3 constitute ca. 80percent of the oligomers formed in ca. 50percent yield from enantiomerically pure 3-hydroxybutanoic acid under Yamaguchi's macrolactonization conditions.The FAB mass spectra of the