An Asymmetric Synthesis of Chiral 4,4-Disubstituted Cyclohexenones in High Enantiomeric Purity

DOI: 10.1021/jo00360a065

Source and publish data:

Journal of Organic Chemistry p. 1936 - 1938 (1986)

Update date:2022-09-26

Topics:

Authors:

Meyers, A. I.

Lefker, Bruce A.

Wanner, Klaus Th.

Aitken, R. Alan

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Article abstract of DOI:10.1021/jo00360a065

An efficient approach to the title compounds in > 95percent ee has been accomplished by metalation and alkylation of chiral bicyclic lactams derived from δ-keto acids and (1S,2S)-2-amino-1-phenyl-1,3-propanediol.

Full text of DOI:10.1021/jo00360a065

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