Mitomycin C analogues with a substituted hydrazine at position 7. Synthesis, spectral properties, and biological activity

DOI: 10.1021/jm00121a044

Source and publish data:

Journal of Medicinal Chemistry p. 248 - 252 (1989)

Update date:2022-08-02

Topics:

Authors:

Sawhney Sawhney

Kohn Kohn

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00121a044

A select number of mitomycin C derivatives with a substituted hydrazine group at position 7 were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Several of the adducts displayed activity comparable to

Full text of DOI:10.1021/jm00121a044

Products guided by the article

Product name:phenylmethyl (1aS-(1aα,8β,8aα,8bα))-(8-{[(aminocarbonyl)oxy]methyl}-1,1a,2,8,8a,8b-hexahydro-4-hydroxy-8a-methoxy-5-methyl-7-oxoazirino[2',3':3,4]pyrrolo[1,2-a]indol-6(7H)-ylidene)hydrazinecarboxylate

Cas No:117606-68-5

R&D Labs maybe for 117606-68-5

Chongqing Yawei Fine Chemical Co.,Ltd

Contact:0086-23-62849407

Address:Ziyou village, Nanquan town, Banan district, Chongqing China
Hangzhou Eastbiopharm Co.,Ltd.

Contact:+86-571-88931780

Address:Hangzhou,China
Wuhan Hanye Chemical New Material Co.,Ltd

Contact:+86-27-85308141

Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
Anhui Eapearl Chemical Co., Ltd.

Contact:86-562-5858458

Address:358 South Huaihe Road
Suzhou CarbonWell Pharma-Tech Co., Ltd

Contact:Tel: + 86 (0)512-8898-1216; + 86-18606258602

Address:2358 Changan Road, Wujiang Scientific Innovation Park, Wujiang, Jiangsu Province, P. R. China 215200

Relevant to this article

Total synthesis of (±)-tricyclohexaprenol, a possible forerunner of sterols in the evolution of biomembranes

Doi:10.1016/S0040-4039(00)96875-8
(1987)
Exploration of the CuAAC reaction for the synthesis of novel 3-(triazol-1-yl)methyl-imidazo[1,2-a]pyridines

Doi:10.1055/s-0032-1317379
(2012)
Asymmetric total synthesis of (-)-plicatic acid via a highly enantioselective and diastereoselective nucleophilic epoxidation of acyclic trisubstitued olefins

Doi:10.1021/ja9039407
(2009)
Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland

Doi:10.1021/tx020019a
(2002)
SYNTHESIS OF 4-PHENYLCOUMARINS FROM DALBERGIA VOLUBILIS AND EXOSTEMA CARIBAEUM

Doi:10.1016/0031-9422(91)83677-D
(1991)
N-HYDROXY-DIAMIN-DERIVATE AUS HYDRAZIN-N-OXYDEN

Doi:10.1016/S0040-4039(00)82075-4
(1988)

Article Doi