DIASTEREOSELECTIVE NUCLEOPHILIC ADDITION TO CHIRAL OPEN-CHAIN α-KETOACETALS: SYNTHESIS OF (R)- AND (S)-MEVALOLACTONE

DOI: 10.1016/S0040-4039(00)84463-9

Source and publish data:

Tetrahedron Letters p. 2117 - 2120 (1986)

Update date:2022-08-04

Topics:

Authors:

Tamura, Yasumitsu

Ko, Tomoko

Kondo, Hiroshi

Annoura, Hirokazu

Fuji, Masahiro

et al. et al.

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Article abstract of DOI:10.1016/S0040-4039(00)84463-9

Highly stereoselective addition of Grignard reagents to chiral open-chain α-ketoacetals (3a,3b) has been attained.Application of the reaction to syntheses of the key intermediates (6,8) for (R)- and (S)-mevalolactone is also described.

Full text of DOI:10.1016/S0040-4039(00)84463-9

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