DIASTEREOSELECTIVE NUCLEOPHILIC ADDITION TO CHIRAL OPEN-CHAIN α-KETOACETALS: SYNTHESIS OF (R)- AND (S)-MEVALOLACTONE

DOI: 10.1016/S0040-4039(00)84463-9

Source and publish data:

Tetrahedron Letters p. 2117 - 2120 (1986)

Update date:2022-08-04

Topics:

Authors:

Tamura, Yasumitsu

Ko, Tomoko

Kondo, Hiroshi

Annoura, Hirokazu

Fuji, Masahiro

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)84463-9

Highly stereoselective addition of Grignard reagents to chiral open-chain α-ketoacetals (3a,3b) has been attained.Application of the reaction to syntheses of the key intermediates (6,8) for (R)- and (S)-mevalolactone is also described.

Full text of DOI:10.1016/S0040-4039(00)84463-9

Products guided by the article

Product name:1-((4S,5S)-4,5-Bis-methoxymethyl-2-phenyl-[1,3]dioxolan-2-yl)-ethanol

Cas No:118026-61-2

R&D Labs maybe for 118026-61-2

Simagchem Corporation

website:http://www.simagchem.com

Contact:+86-592-2680277

Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China
Xinji City Taida Sinopec Co., Ltd.

Contact:0086-311-85341278

Address:No.6, Nanhua Road,Xinji City Road,Hebei Province,China
Ningbo Huajia Chemicals

Contact:+86-574-87065746

Address:10th Floor, No.787 Baizhang East Road,
NINGBO PANGS CHEM INT’L CO.,LTD.

Contact:+86-574-27666845

Address:FLOOR 21,BUILDING NO.11,XIN TIAN DI,NO.689 SHI JI ROAD,NINGBO CHINA
Wuxi D-Stone International Co., Ltd.

Contact:+86-510-82740567

Address:21F Hengtong Int'l Centre, 215Zhongshan Road, Wuxi, Jiangsu,China

Relevant to this article

Lewis Acid Promoted Reactions of Substituted Pentacyclo<5.4.0.0.^2,6.0^3,10.0^5,9>undecane-8,11-diones with Ethyl Diazoacetate

Doi:10.1021/jo00262a041
(1989)
PARTIALLY FLUORINATED HETEROCYCLIC COMPOUNDS. PART 24. A PLAUSIBLE MECHANISM FOR THE FORMATION OF THE FISCHER INDOLE PRODUCT FROM ACETOPHENONE 1,3,4,5,6,7,8,-HEPTAFLUORO-2-NAPHTHYLHYDRAZONE IN WHICH o-FLUORINE IS LOST

Doi:10.1016/S0022-1139(00)81061-1
(1988)
Synthesis of apogalanthamine analogs as α-adrenergic blocking agents. IX [1]. Syntheses of optically active 8-hydroxy-6-methyl-5,6,7,8-tetrahydrodibenz[c,e]azocines

Doi:10.1002/jhet.5570250123
(1988)
Indole-derived arynes and their diels - Alder reactivity with furans

Doi:10.1021/ol701595n
(2007)
Ortho-Metalated Aryl tert-Butyl Sulfones, Comparison with Other Directing Groups and New Methodology for Polysubstituted Aromatics

Doi:10.1021/jo00262a012
(1989)
A class of novel N-isoquinoline-3-carbonyl-l-amino acid benzylesters: Synthesis, anti-tumor evaluation and 3D QSAR analysis

Doi:10.1016/j.ejmech.2011.02.017
(2011)

Article Doi