Synthesis and Structure-Activity Studies of Some Disubstituted Phenylisoxazoles against Human Picornavirus

Article abstract of DOI:10.1021/jm00122a027

A number 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes.A QSAR study revealed that the mean MIC (<*>) against five rhinovirus serotypes correlated well with log P.The 2,6-dichloro analogue, 15, was highly effective in vitro against rhinoviruses with an MIC₈₀ of 0.3 μM, as well as against several enteroviruses, and was also effective in preventing paralysis in mice infected with coxsackievirus A-9.