Erratum: The benzyne aza-claisen reaction (Angewandte Chemie - International Edition (2009) (48))

Full text of DOI:10.1002/anie.201206624

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Angewandte
Contents
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Angewandte
Corrigendum
Compounds 14a, 14b, and 14c in Table 3 of this communication were incorrectly
reported as having the alkene E configuration. The correct configuration is Z. The
correct table is shown below and a revised Supporting Information accompanies this
corrigendum. The authors apologize for this mistake.
The Benzyne Aza-Claisen Reaction
A. A. Cant, G. H. V. Bertrand,
J. L. Henderson, L. Roberts,
M. F. Greaney*
5199–5202
Table 3: Synthesis of medium-ring amines using the benzyne aza-
Claisen rearrangment.[a]
Angew. Chem. Int. Ed. 2009, 48
DOI: 10.1002/anie.200901410
Entry
1
Amine
Product
Yield [%][b]
13a
13b
14a
14b
41
2[c]
40
28
3
13c
14c
[a] Reaction conditions: o-trimethylsilylphenyl triflate (1 equiv), amine
(1.5 equiv), and CsF (3 equiv) in toluene (0.75 mL) and MeCN
(0.25 mL). Reactions were carried out on a 0.2 mmol scale and were
stirred for 24 hours at room temperature and then heated at reflux for
48 hours in a sealed tube. [b] Yield of isolated product. [c] 2 equivalents
of o-trimethylsilylphenyl triflate to 1 equivalent of amine was used. Bn=
benzyl.