Journal of Organic Chemistry p. 4279 - 4288 (2020)
Update date:2022-08-04
Topics:
Kim, Sugyeom
Lannigan, Deborah A.
Li, Yu
Lin, Lin
O'Doherty, George A.
Sayasith, Peyton R.
Tarr, Ariel T.
Wright, Eric B.
Yasmin, Sharia
The synthesis of two series of five kaempfer-3-ols was described. The first set all have a C-3 hydroxyl group and the second has a carboxymethoxy ether at the C-3 position. Both series have variable substitution at the C-4 position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proliferation.
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