Tetrahedron Letters p. 2059 - 2062 (1988)
Update date:2022-09-26
Topics:
Carretero, Juan Carlos
Ghosez, Leon
The lithio derivative of methyl 3-phenylsulphonylorthopropionate 1 reacts with epoxides to give, after acidic work-up and treatment with p-toluenesulphonic acid, β-phenylsulphonyl δ-lactones 2.These are directly converted into the corresponding α,β-unsaturated δ-lactones 3 upon treatment with triethylamine or DBU.An application of this new method to the synthesis of (-)-argentilactone 4 is described.
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