Journal of Medicinal Chemistry p. 913 - 927 (2017)
Update date:2022-08-15
Topics:
Tran, Thuy-Anh
Kramer, Bryan
Shin, Young-Jun
Vallar, Pureza
Boatman, P. Douglas
Zou, Ning
Sage, Carleton R.
Gharbaoui, Tawfik
Krishnan, Ashwin
Pal, Biman
Shakya, Sagar R.
Garrido Montalban, Antonio
Adams, John W.
Ramirez, Juan
Behan, Dominic P.
Shifrina, Anna
Blackburn, Anthony
Leakakos, Tina
Shi, Yunqing
Morgan, Michael
Sadeque, Abu
Chen, Weichao
Unett, David J.
Gaidarov, Ibragim
Chen, Xiaohua
Chang, Steve
Shu, Hsin-Hui
Tung, Shiu-Feng
Semple, Graeme
The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues resulted in
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