New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8- fluoro group with reduced phototoxic risk

DOI: 10.1021/jm00080a023

Source and publish data:

Journal of Medicinal Chemistry p. 361 - 367 (1992)

Update date:2022-08-04

Topics:

Authors:

Sanchez Sanchez

Bridges Bridges

Bucsh Bucsh

Domagala

Gogliotti

Hagen Hagen

Heifetz Heifetz

Joannides

Sesnie Sesnie

Shapiro Shapiro

Szotek Szotek

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00080a023

A series of 8-(trifluoromethyl)-substituted quinolones has been prepared and evaluated for in vitro and in vivo antibacterial activity, and phototolerance in a mouse phototolerance assay. These analogues were compared to the corresponding series of 6,8-di

Full text of DOI:10.1021/jm00080a023

Products guided by the article

Product name:Benzene, 1-bromo-2,4,5-trifluoro-3-(trifluoromethyl)-

Cas No:118829-13-3

R&D Labs maybe for 118829-13-3

Lanzhou huibang biological chemical technology Co., LTD

Contact:0931-7843964

Address:NO.2011,Yannan Road,Chengguan,
ZK Biochem Group Co., Ltd

Contact:+86-532-80762375

Address:No. 6, Hongkong Middle Road, Qingdao, China
Tianjin Jiuri New Materials Co., Ltd.

Contact:+86-22-58889220

Address:C-5/6, Vison Hill, No.1 Gonghua Road, Huayuan Hi-tech Park, Tianjin, China.
He Bei Shun Er Chemical Co., LTD.

Contact:86-0311-86996932/86860168

Address:No 18,North street
Chengdu ZY Biochemical Technology Co., LTD

Contact:0086-28-88680086

Address:170 Qingpu Road, Shouan Town, Pujiang County

Relevant to this article

Photochemical Hydrogen Abstraction from Cymenes

Doi:10.1021/jo00270a025
(1989)
Total Synthesis of (+/-)-Vallesamidine

Doi:10.1021/ja00186a074
(1989)
Doi:10.1086/315901
(1958)
A palladium-catalyzed synthesis of isatins (1H-Indole-2,3-diones) from 1-(2-haloethynyl)-2-nitrobenzenes

Doi:10.1016/j.tet.2009.06.098
(2009)
InCl₃ mediated one-pot synthesis of indol-3-yl pyridine and 2,2′-bipyridine derivatives through multi-component reaction

Doi:10.1016/j.tet.2009.06.097
(2009)
Copper-catalyzed asymmetric allylation of chiral N-tert-butanesulfinyl imines: Dual stereocontrol with nearly perfect diastereoselectivity

Doi:10.1039/c5ob00322a
(2015)

Article Doi