New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8- fluoro group with reduced phototoxic risk

DOI: 10.1021/jm00080a023

Source and publish data:

Journal of Medicinal Chemistry p. 361 - 367 (1992)

Update date:2022-08-04

Topics:

Authors:

Sanchez Sanchez

Bridges Bridges

Bucsh Bucsh

Domagala

Gogliotti

Hagen Hagen

Heifetz Heifetz

Joannides

Sesnie Sesnie

Shapiro Shapiro

Szotek Szotek

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Article abstract of DOI:10.1021/jm00080a023

A series of 8-(trifluoromethyl)-substituted quinolones has been prepared and evaluated for in vitro and in vivo antibacterial activity, and phototolerance in a mouse phototolerance assay. These analogues were compared to the corresponding series of 6,8-di

Full text of DOI:10.1021/jm00080a023

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Product name:Benzene, 1-bromo-2,4,5-trifluoro-3-(trifluoromethyl)-

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