DIASTEREOSPECIFIC ADDITION OF ORGANOMETALLICS TO (S)-2-ALKOXY-1-(1,3-DITHIAN-2-YL)-1-PROPANONES AND ITS APPLICATION TO THE SYNTHESIS OF (-)-TRACHELANTHIC ACID.

Article abstract of DOI:10.1016/S0040-4039(00)80392-5

Nucleophilic addition of organometallics to (S)-2-alkoxy-1-(1,3-dithian-2-yl)-1-propanones afforded preferentially (1R,2S)-2-alkoxy-1-alkyl-1-(1,3-dithian-2-yl)-1-propanols.The utility of the present reaction was demonstrated in the synthesis of (2R,3S)-t