A general approach to the synthesis of bisindolylmaleimides: Synthesis of staurosporine aglycone

DOI: 10.1055/s-1995-4146

Source and publish data:

Synthesis p. 1511 - 1516 (1995)

Update date:2022-08-05

Topics:

Authors:

Faul Faul

Sullivan

Winneroski

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Article abstract of DOI:10.1055/s-1995-4146

Bisindolylmaleimides are prepared in 65-95% yield by reaction of an indole Grignard with either 2,3-dichloro-N-methylmaleimide or 2,3-dichloromaleimide. A one-step synthesis of arcyriarubin A in 72% yield affords ready access to the staurosporine aglycone

Full text of DOI:10.1055/s-1995-4146

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Product name:2,3-bis-(2-phenyl-1H-indol-3-yl)-N-methylmaleimide

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