Total synthesis of 8-methoxygoniodiol related compounds via chiron approach

Article abstract of DOI:10.1016/j.tetasy.2009.05.034

The stereoselective synthesis of 8-methoxygoniodiol related compounds was accomplished by using readily available δ-gluconolactone as a chiral source. The stereoselective addition of an aryl Grignard reagent on an aldehyde, stereoselective reduction of a keto group and regioselective opening of a chiral epoxide by ethyl propiolate are the key steps involved in this synthesis.