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Scheme 4 Pd-catalyzed cross-couplings of 2a with arylboronic acids.
In conclusion, we have described a novel and efficient
method for the synthesis of highly functionalized 1-methylene-
indenes via sequential Pd-catalyzed tandem cyclization and
cross-coupling reactions of 2-alkenylphenylacetylenes 1. The
use of the substrates in other transformations is under
investigation, and the results will be reported in due course.
Financial support from the National Natural Science
Foundation of China (20772018) is gratefully acknowledged.
Notes and references
y Crystal data and structure refinement for compound 4a: empirical
formula C26H22O2 (molecular weight = 366.44), crystal system =
monoclinic, unit cell dimensions a = 10.1464(3), b = 10.1719(3),
c
= 10.4892(3) A, a = 72.9430(10), b = 79.8270(10), g =
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ꢀc
This journal is The Royal Society of Chemistry 2009
5408 | Chem. Commun., 2009, 5406–5408