Enantioselective intramolecular Michael addition of nitronates onto conjugated esters: Access to cyclic γ-amino acids with up to three stereocenters

Article abstract of DOI:10.1021/ja9070915

(Chemical Equation Presented) A highly stereoselective synthesis of conformationally constrained cyclic γ-amino acids has been devised. The key step involves an intramolecular cyclization of a nitronate onto a conjugated ester, promoted by a bifunctional