Bioorganic and Medicinal Chemistry Letters p. 5872 - 5876 (2009)
Update date:2022-08-05
Topics:
Haque, Tasir S.
Liang, Ningning
Golla, Rajasree
Seethala, Ramakrishna
Ma, Zhengping
Ewing, William R.
Cooper, Christopher B.
Pelleymounter, Mary Ann
Poss, Michael A.
Cheng, Dong
We report the synthesis and enzymatic evaluation of potent inhibitors of acetyl-CoA carboxylases (ACCs) containing biphenyl or 3-phenyl pyridine cores. These compounds inhibit both ACC1 and ACC2, or are moderately selective for either enzyme, depending on
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Doi:10.1007/BF00854036
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