Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists

DOI: 10.1016/j.bmcl.2009.08.076

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 6237 - 6240 (2009)

Update date:2022-07-30

Topics:

Authors:

Pasternak, Alexander

Goble, Stephen D.

deJesus, Reynalda K.

Hreniuk, Donna L.

Chung, Christine C.

Tota, Michael R.

Mazur, Paul

Feighner, Scott D.

Howard, Andrew D.

Mills, Sander G.

Yang, Lihu

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Article abstract of DOI:10.1016/j.bmcl.2009.08.076

This Letter describes optimization of ghrelin receptor antagonists and inverse agonists starting from a screening hit.

Full text of DOI:10.1016/j.bmcl.2009.08.076

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