Tetrahedron Letters p. 5095 - 5098 (1988)
Update date:2022-07-30
Topics:
Fancher, L.W.
Gless, R.D.
Wong, R.Y.
N-(2-Alkoxyethyl)anilines may be prepared by acylation of an N-unsubstituted aniline with 2-chloroethyl chloroformate, ring closure to oxazolidinone, ring opening with alkoxide under anhydrous conditions to a carbamic acid salt, and decarboxylation.This unexpected mode of ring opening is especially useful in the preparation of N-(2-alkoxyethyl)-2,6-disubstituted anilines.
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(2009)Doi:10.1016/j.jfluchem.2015.09.015
(2015)Doi:10.1002/jhet.230
(2009)Doi:10.1016/S0040-4039(00)80531-6
(1988)Doi:10.1016/0040-6031(89)85405-X
(1989)
