Mono and bis(bioreductive) alkylating agents: Synthesis and antitumor activities in a B16 melanoma model

Article abstract of DOI:10.1021/jm00127a039

Several potentially bis(alkylating) bis(quinones) (3-5) and 1,4- and 1,3-bis(alkylating) monoquinones (6-13) belonging to general structure 2,2'-ethylenebis[5-[(leaving group) methyl]-1,4-benzoquinone] (3-5) and 2,5- and 2,6-bis[(leaving group)methyl]-1,4