C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.

Article abstract of DOI:10.1021/jm00128a002

Extracellular adenosine receptors have been divided into two major subtypes, called A1 and A2. Substitution of the adenosine molecule with appropriate groups at C2 or N6 is known to impart selectivity for the A2 receptor over the A1 receptor. In the prese