Convenient Preparation of Alkyl Benzyl Imidodicarbonates, Useful Reagents for the Direct Synthesis of Protected Amines

DOI: 10.1055/s-1988-27780

Source and publish data:

Synthesis p. 992 - 994 (1988)

Update date:2022-09-26

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Authors:

Grehn, Leif

Almeida, M. Lurdes S.

Ragnarsson, Ulf

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Article abstract of DOI:10.1055/s-1988-27780

New mixed alkyl benzyl imidodicarbonates were prepared by reaction of benzyloxycarbonyl isocyanate with appropriate alcohols.This simple procedure also furnished alternative, more convenient routes to dibenzyl and benzyl 9-fluorenylmethyl imidodicarbonates.The substances are of interest as potential Gabriel reagents.Completely selective removal of one of the alkoxycarbonyl groups from the N-atom of the imidodicarbonates was demonstrated in several instances, giving benzyl carbamate or the alternative carbamate.

Full text of DOI:10.1055/s-1988-27780

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