Molecules 2018, 23, 1506
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(m, 1H, H2), 2.83–2.63 (m, 2H, H3, H30 ), 2.42 (s, 3H, CH3Ts), 1.38 (d, 3H, J = 6.2 Hz, CH3) ppm. FT-IR
(KBr):
ν
3375, 3328, 3078, 2984, 2919, 1713, 1699, 1598, 1383, 1297, 1193, 1180 cm−1. MS (ESI): m/z calcd
for C18H16SO7 376.30, found m/z 377.32 [M + H]+.
3.1.3. Synthesis of 2-Methyl-4-oxo-3,4-dihydro-2H-benzopyran-5-carboxylic acid (3)
To a stirred solution of 1a (1.25 g, 3.3 mmol) in 0.2 M NaHCO3 (75 mL), a suspension of Raney
Nickel (1:5 w/w) catalyst was added. The mixture was stirred over a period of 6 h at room temperature.
Then, the catalyst was filtered through a celite pad; the filtrate was acidified with 4 M HCl (15 mL)
until pH 2–3 and extracted with diethyl ether (3
over anhydrous Na2SO4, filtered and evaporated in vacuo, affording the pure
m.p. 167–168 ◦C. 1H-NMR (300 MHz, DMSO-d6):
12.85 (broad s. exch D2O, 1H, COOH), 7.54 (t,
1H, J = 8.4, Hz, H7), 7.07 (d, 1H, J = 8.4 Hz, H6), 6.93 (d, 1H, J = 7.3 Hz, H8), 4.70–4.63 (m, 1H, H2),
2.71–2.57 (m, 2H, H3, H30 ), 1.41 (d, 3H, J = 6.2 Hz, CH3) ppm. 13C-NMR (75 MHz, DMSO-d6):
191.58,
3338, 2979,
×
25 mL). The combined organic layers were dried
3. Quantitative yield,
δ
δ
170.79, 161.76, 136.29, 136.26, 120.07, 119.41, 117.62, 74.83, 44.51, 21.05 ppm. FT-IR (KBr):
ν
2918, 1703, 1683, 1596, 1484, 1298 cm−1. MS (ESI): m/z calcd for C11H10O4 206.19 found m/z 207.87
[M + H]+.
HRMS (ESI-QTOF) calcd. for C11H10O4: [M − H]− 205.0501; found: 205.0502.
3.1.4. Synthesis of 2-Methyl-3,4-dihydro-2H-benzopyran-5-carboxylic acid (4)
Pd/BaSO4 (264 mg, 0.8 mmol) was stirred in anhydrous ethanol (5 mL), then
3 (90 mg, 0.4 mmol),
previously dissolved in anhydrous ethanol (5 mL), was added. The resulting mixture was reduced
with hydrogen in autoclave at 5 atm for 6 h at room temperature. After completion of the reaction,
the catalyst was filtered off on a celite pad, the filter cake was rinsed with ethanol, and the filtrate was
evaporated under reduced pressure. The residue was dissolved in ethyl acetate (5 mL), diluted with
water (2 mL), acidified with 10% HCl (2 mL) until pH = 2, and extracted with ethyl acetate (3
The combined organic layers were dried over anhydrous Na2SO4, filtered and evaporated in vacuo to
×
5 mL).
give a solid residue, which was then purified by chromatographic column (ethyl acetate/methanol
1
9:1), to obtain
4
as an oil. Yield 70%. H-NMR (300 MHz, DMSO-d6):
δ
12.64 (broad s. exch D2O, 1H,
COOH), 7.35 (dd, 1H, J = 7.6, 1.3 Hz, H6), 7.14 (t, 1H, J = 7.6, Hz, H7), 6.92 (d, 1H, J = 7.6 Hz, H8),
4.14–4.06 (m, 1H, H2), 3.03 (ddd, 1H, J = 18.0, 5.8, 3.2 Hz, H3), 2.95 (ddd, 1H, J = 18.0, 11.5, 6.2 Hz, H30 ),
2.05–1.96 (m, 1H, H4), 1.61–1.47 (m, 1H, H4’), 1.32 (d, 3H, J = 6.2 Hz, CH3) ppm. 13C-NMR (75 MHz,
DMSO-d6):
(KBr):
δ 168.93, 155.60, 131.93, 126.98, 123.45, 122.44, 120.60, 71.76, 28.91, 23.84, 21.44 ppm. FT-IR
ν
3429.8, 2968.8, 2928.8, 2645.1, 1687.9, 1594.4, 1457.8, 1278.7, 1139.9, 1109.1, 801.2 cm−1. MS (ESI):
m/z calcd for C11H12O3 192.20, found m/z 191.20 [M − H]−.
HRMS (ESI-QTOF) calcd. for C11H12O3: [M − H]− 191.0708; found: 191.0709.
3.1.5. Synthesis of 7-Hydroxy-2-methylchroman-5-carboxylic acid (5)
Pd/BaSO4 (0.55 g, 1.62 mmol) was stirred in anhydrous ethanol (15 mL), then 1 (0.2 g, 0.90 mmol),
dissolved in 10 mL of anhydrous ethanol, was charged. The resulting mixture was stirred under
hydrogen flow in autoclave at 5 atm for 6 h at room temperature. After completion of the reaction,
the catalyst was filtered through a celite pad, the filter cake was rinsed with ethanol, and the filtrate
was evaporated under reduced pressure. The residue was dissolved in ethyl acetate (10 mL) and then
washed with 2 M HCl (3
evaporated in vacuo to give
DMSO-d6) 12.64 (broad s, exch. D2O, 1H, COOH), 9.40 (broad s, exch. D2O 1H, OH), 6.82 (d,
×
5 mL). The organic layer was dried over anhydrous Na2SO4, filtered and
5
◦
as a yellow solid. Yield 75%, m.p. 168–170 C. 1H-NMR (300 MHz,
δ
J = 2.6 Hz, 1H, H6), 6.32 (d, J = 2.6 Hz, 1H, H8), 4.21–3.87 (m, 1H, H2), 2.96 (dd, J = 5.6, 3.1 Hz, 1H, H3),
2.90 (dd, J = 5.6, 3.1 Hz, 1H, H30 ), 2.01–1.86 (m, 1H, H4), 1.63–1.37 (m, 1H, H40 ), 1.27 (d, J = 6.2 Hz,
3H, CH3) ppm.13C-NMR (75 MHz, DMSO-d6):
δ
168.87, 156.42, 156.06, 132.18, 114.15, 110.27, 107.09,
71.79, 29.21, 23.30, 21.43 ppm. FT-IR(KBr):
ν 3370, 2972, 2945, 2618, 1697, 1622, 1589, 1491, 1410,1308,
1132 cm−1. MS (ESI): m/z calcd for C11H12O4 208.07, found m/z 207.21 [M − H]−.