Diethylstilbestrol-linked cytotoxic agents: Synthesis and binding affinity for estrogen receptors

Article abstract of DOI:10.1021/jm00127a022

The syntheses of diethylstilbestrol derivatives with a C₄ side chain at the double bond bearing various functional and potentially alkylating groups (9-25, 38-40, 43-44) as well as the coupling product with daunorubicine (41) are described. Der