N2-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA

DOI: 10.1021/ol100019r

Source and publish data:

Organic Letters p. 1044 - 1047 (2010)

Update date:2022-08-04

Topics:

Authors:

Peacock, Hayden

Maydanovych, Olena

Beal, Peter A.

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Article abstract of DOI:10.1021/ol100019r

"Chemical equation presented" Nucleoside analogs that project substituents Into the minor groove when incorporated into duplex RNA perturb the binding of proteins and can affect base pairing specificity. The synthesis of 2-amlnopurine ribonucleoside analo

Full text of DOI:10.1021/ol100019r

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