Differential Effects of a Series of Hydroxamic Acid Derivatives on 5-Lipoxygenase and Cyclooxygenase from Neutrophils and 12-Lipoxygenase from Platelets and Their in Vivo Effects on Inflammation and Anaphylaxis

DOI: 10.1021/jm00128a027

Source and publish data:

Journal of Medicinal Chemistry p. 1836 - 1842 (1989)

Update date:2022-08-04

Topics:

Authors:

Huang, Fu-Chih

Shoupe, T. Scott

Lin, Clara J.

Lee, Thomas D. Y.

Chan, Wan-Kit

et al. et al.

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Article abstract of DOI:10.1021/jm00128a027

The synthesis of a series of novel substituted hydroxamates has been described along with their profile of inhibitory activity against 5-lipoxygenase, 12-lipoxygenase, and cyclooxygenase enzymes.The structure-activity relationship suggests that future mol

Full text of DOI:10.1021/jm00128a027

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