Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements

DOI: 10.1021/jm00126a039

Source and publish data:

Journal of Medicinal Chemistry p. 1378 - 1392 (1989)

Update date:2022-07-30

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Authors:

Harbeson

Rich Rich

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Article abstract of DOI:10.1021/jm00126a039

Inhibitors of aminopeptidase enzymes have been prepared by the synthesis of peptide substrate analogues in which the scissile amide bond has been replaced with the hydrolytically stable ketomethylene (-COCH₂-) and hydroxyethylene [-CH(OH)CH View More

Full text of DOI:10.1021/jm00126a039

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