Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements

DOI: 10.1021/jm00126a039

Source and publish data:

Journal of Medicinal Chemistry p. 1378 - 1392 (1989)

Update date:2022-07-30

Topics:

Authors:

Harbeson

Rich Rich

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00126a039

Inhibitors of aminopeptidase enzymes have been prepared by the synthesis of peptide substrate analogues in which the scissile amide bond has been replaced with the hydrolytically stable ketomethylene (-COCH₂-) and hydroxyethylene [-CH(OH)CH View More

Full text of DOI:10.1021/jm00126a039

Products guided by the article

Product name:benzyl (5S)-2-(benzyloxycarbonyl)-5-<(tert-butyloxycarbonyl)amino>-2,7-dimethyl-4-oxooctanoate

Cas No:121142-31-2

R&D Labs maybe for 121142-31-2

Chengdu Push Bio-technology Co., Ltd

Contact:86-28-85370565

Address:No.8 Wuke West Second Road, Wuhou
AUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD

Contact:+86-25-86883560 15951806178

Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.
Shaanxi HuaTai Bio-fine chemical company Ltd

Contact:86-029-87862197

Address:No. 5, 3rd Floor, 29 Yanta North Road, Beilin Dist.
Yingkou Sanzheng New Technology Chemical Industry Co., Ltd.

Contact:+86-417-2927806

Address:yingkou
Weinan Rigel Pharm Co., Ltd.

Contact:+86-913-2223392

Address:No. 32, Xinanjing Road, Weinan City, Shaanxi Province, 714000, China

Relevant to this article

Facile Synthesis of Carbazoles via a Tandem Iodocyclization with 1,2-Alkyl Migration and Aromatization

Doi:10.1021/acs.orglett.5b01590
(2015)
Chiral zinc(II) and copper(II)-catalyzed asymmetric ring-opening reactions of meso-epoxides with aniline and indole derivatives

Doi:10.1016/j.tet.2009.11.018
(2010)
Catalytic enantioselective mannich-type reaction via a chiral silver enolate

Doi:10.1021/ol403075u
(2014)
Rational design, synthesis, and potency of N-substituted indoles, pyrroles, and triarylpyrazoles as potential fructose 1,6-bisphosphatase inhibitors

Doi:10.1002/cmdc.200900493
(2010)
Enantioselective 5-endo-dig carbocyclization of β-ketoesters with internal alkynes employing a four-component catalyst system

Doi:10.1002/anie.201201060
(2012)
SAR and lead optimization of an HIV-1 Vif-APOBEC3G axis inhibitor

Doi:10.1021/ml300037k
(2012)

Article Doi