Substituent-Directed Alkyl Addition Reactions of Epoxides. 1. Applications to the Synthesis of 3-Hydroxy-4-methylalkanoic Acids

DOI: 10.1021/jo00276a018

Source and publish data:

Journal of Organic Chemistry p. 3588 - 3596 (1989)

Update date:2022-08-04

Topics:

Authors:

Flippin, Lee A.

Brown, Peter A.

Jalali-Araghi, Keyvan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00276a018

The addition reactions of 3,4-epoxy-1-alkanol derivatives were studied using Li(CH3)2Cu (ether, 0 deg C) and 2:1 (CH3)3Al-n-BuLi or 2:1 (C2H5)3Al-n-BuLi (hexane, 0 deg C).In all cases Li(CH3)2Cu showed a small (2-3:1) preference for C(4) addition over C(3

Full text of DOI:10.1021/jo00276a018

Products guided by the article

Product name:(3RS,4RS)-1-methoxy-3,4-epoxyhexane

Cas No:121441-16-5

R&D Labs maybe for 121441-16-5

Suzhou Health Chemicals Co., Ltd.

website:http://www.healthchems.com

Contact:13776257979

Address:No. 338, Jingang Avenue,
Jurong Huaheng Natural Biological Products Factory

website:http://www.risebiochem.com

Contact:+86-13921007726

Address:Chuncheng town,Jurong city,Jiangsu province,China
LianYunGang Chiral Chemical(CHINA) CO.,LTD

Contact:+86-518-83616958 +86-519-82884848

Address:LianYunGang Chemical Industry Park (JiangSu)
enantiotech corporation ltd

Contact:+86-0760-85282375

Address:zhongjing road,zhongshan torch hi-tech industrial development zone
Anhui Redstar Pharmaceutical Corp., Ltd

Contact:+86-563-5120837

Address:Jingxian Industrial Development Zone, Anhui , China

Relevant to this article

Remarkable enantioselective α-amination in 1-phenyl-2-(N-alkylamino)- 1-propanol

Doi:10.1002/chir.21996
(2012)
Reaction of Carbamoyl-S-benzylcarbodithiolate with Dipolarophiles

Doi:10.1021/jo00276a030
(1989)
Desymmetric enantioselective reduction of cyclic 1,3-diketones catalyzed by a recyclable p-chiral phosphinamide organocatalyst

Doi:10.1021/jacs.1c00277
(2021)
Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): Identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′ H -spiro[chromeno[2,3- b ]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

Doi:10.1021/jm5012676
(2014)
Regioselective synthesis of multiply halogenated azaxanthones

Doi:10.1016/j.tetlet.2014.11.032
(2014)
1,6-ADDITION OF ORGANOCOPPER REAGENTS TO 3-ETHYNYL-2-METHYL-2-CYCLOPENTENONE

Doi:10.1016/S0040-4039(00)82207-8
(1988)

Article Doi