Tricyclic heteroaromatic systems: Synthesis, [3H]flunitrazepam brain membrane binding inhibition, and structure-activity relationships of 2,3-dihydro-2-aryl-4-R-[1]benzopyrano[4,3-c]pyrazole-3-ones

Article abstract of DOI:10.1002/jps.2600780314

We report the synthesis and binding activity to the central benzodiazepine receptors of some 2,3-dihydro-2-ary-4-R-[1]benzopyrano[4,3-c]pyrazole-3-ones, which are isosteres of the CGS series. Although the compounds of the CGS series are potent ligands of